மார்ச்சு 25, 2023 இதழ்
தமிழ் வார இதழ்

Anastrozole: MedlinePlus Drug Information

வழக்கறிஞர் ராஜாசுந்தர் ராமன்

Feb 6, 2024

Anastrozole: MedlinePlus Drug Information

If you forget to take a dose of Arimidex, take the missed dose as soon as you remember. However, if it’s almost time for your next dose, just skip the missed dose and take your next dose as usual. Don’t take two doses together to make up for a missed dose. If you have heart palpitations while you’re taking Arimidex, call your doctor right away.

  • No significant differences were seen between treatment groups.
  • Patients receiving tamoxifen had a mean increase in both lumbar spine and total hip BMD compared to baseline.
  • (Arimidex is considered a hormone therapy.) But keep in mind that this is an off-label use of the drug.
  • The suppression of estrogen biosynthesis in peripheral tissuesand in the cancer tissue itself can therefore be achieved by specificallyinhibiting the aromatase enzyme.

They can give you advice on much alcohol is safe for you to drink. By stopping aromatase from working, Arimidex lowers the amount of estrogen in your body. This helps to stop estrogen from encouraging breast cancer to grow and spread.

A randomized, double-blind, placebo-controlled,multi-center study enrolled 80 boys with pubertal gynecomastia aged 11 to 18years. Patients were randomized to a daily regimen of either ARIMIDEX 1 mg orplacebo. After 6 months of treatment there was no statistically significantdifference in the percentage of patients who experienced a ≥ 50% reductionin gynecomastia (primary efficacy analysis). Serum estradiol concentrationsat Month 6 of treatment were reduced by 15.4% in the ARIMIDEX group and 4.5% inthe placebo group. Mean serum total cholesterollevels increased by 0.5 mmol/L among patients receiving ARIMIDEX.

Anastrozole is a medication that may be used to treat postmenopausal breast cancer and works by lowering estrogen levels in the body. It is usually taken for five years and hot flushes are the most common side effect. It reduces the risk of breast cancer by 53% after 7 years of follow-up, and 50% after 10.9 years of follow-up. Anastrozole inhibited reactions catalyzed by cytochromeP450 1A2, 2C8/9, and 3A4 in vitro with Ki values which were approximately 30times higher than the mean steady-state Cmax values observed following a 1 mgdaily dose. Anastrozole had no inhibitory effect on reactions catalyzed bycytochrome P450 2A6 or 2D6 in vitro.

Other uses for Arimidex

Some breast cancers are made to grow faster by a natural hormone called estrogen. Anastrozole decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers. Although it is not likely that a postmenopausal woman would be pregnant, anastrozole may harm an unborn baby. You may need to have a negative pregnancy test before starting this treatment.

Arimidex

Anastrozole is used with other treatments, such as surgery or radiation, to treat early breast cancer in women who have experienced menopause (change of life; end of monthly menstrual periods). This medication is also used in women, who have experienced menopause, as a first treatment of breast cancer that has spread within the breast or to other areas of the body. This medication is also used to treat breast cancer in women whose breast cancer has worsened after taking tamoxifen (Nolvadex). Anastrozole is in a class of medications called nonsteroidal aromatase inhibitors.

Patients with pre-existing ischemic heart disease should be informed that an increased incidence of cardiovascular events has been observed with Anastrozole use compared to tamoxifen use. In multiple daily dosing trials with 5 and 10 mg, thyroid stimulating hormone (TSH) was measured; there was no increase in TSH during the administration of Anastrozole. Anastrozole steroids for sale in USA does not possess direct progestogenic, androgenic, or estrogenic activity in animals, but does perturb the circulating levels of progesterone, androgens, andestrogens. During the ATAC trial, more patients receiving Anastrozole were reported to have an elevated serum cholesterol compared to patients receiving tamoxifen (9% versus 3.5%, respectively).


வழக்கறிஞர் ராஜாசுந்தர் ராமன்

இவரது மற்ற கட்டுரைகளைக் காண இங்கே சொடுக்குங்கள்.

கருத்துக்கள் பதிவாகவில்லை- “Anastrozole: MedlinePlus Drug Information”

அதிகம் படித்தது